If you like reading randomized trials about skin and oral health treatments - and who doesn't? - you come across a few split-face and split-mouth ones. Instead of randomizing groups of people to different interventions so that a group of people can be a control group (parallel trials), sections of a person are randomized. It's not only done with faces and teeth. Pairs of body parts can be randomized too, like arms or legs. These studies are sometimes called "within-person" trials. This kind of randomization means that you need fewer people in the trial , because you don't have to account for all the variations between human beings. It has to be a treatment that affects only the specific area of the body treated, though. Anything that could have an influence on the "control" part is called a spill-over effect . There are still inevitably things that happen that affect the whole person, and those have to be accounted for with this kind of trial. Body part